Melatonin releases from the pineal gland, reaching its peak at night to help maintain tissues in a youthful state of health. Secretion of melatonin declines significantly with age, as the pineal gland becomes calcified. This melatonin formulation is for those who need the fastest possible sleep inducing action. By dissolving in the mouth, melatonin goes directly to the brain and bypasses the liver where much of orally ingested melatonin can be metabolized (in some people) before it reaches the brain. Melatonin most effectively supports nighttime sleep when taken 15 minutes before bedtime.